Showing results for 'D'
Total number of hits: 38
Click on results for more details:
PDIDD001
Dabigatran Etexilate
Active compound: Dabigatran
Indications: Anticoagulant
Target: Prothrombin
PDIDD002
Dabigatran etexilate
Active compound: Dabigatran
Indications: Venous thromboembosis
Target: Prothrombin enzyme
PDIDD003
Dacarbazine
Active compound: 5-Aminoimidazole-4-Carboxamide
Indications: malignant melanoma, Hodgkin's lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
Target: na
PDIDD004
D-alanine
Active compound: Hydrogen peroxide
Indications: Cancer
Target: DNA, Proteins and Lipids
PDIDD005
Dasolampanel
Active compound: Tezampanel
Indications: Migraine
Target: AMPA- and KA-subtype ionotropic Glu receptors
PDIDD006
DC-81 prodrug
Active compound: DC-81
Indications: Cancer
Target: DNA minor groove
PDIDD007
D-Deprenyl
Active compound: D-methamphetamine
Indications: Na
Target: na
PDIDD007
D-Deprenyl
Active compound: D-amphetamine
Indications: Attention deficit disorder, hyperactivity and narcolepsy
Target: na
PDIDD008
Deflazacort
Active compound: 21-desacetyldeflazacort
Indications: Duchenne muscular dystrophy
Target: Glucocorticoid receptor
PDIDD009
Delamanid
Active compound: Delamanid- intermediates (still to-be-identified) (R6)
Indications: Tuberculosis
Target: Mycolic acid synthesis
PDIDD010
Delapril
Active compound: 5-hydroxydelapril diacid
Indications: Hypertension and heart failure
Target: Converting enzyme inhibitor (CEI); ACE inhibitor
PDIDD010
Delapril
Active compound: Delapril diacid
Indications: Hypertension and heart failure
Target: Converting enzyme inhibitor (CEI); ACE inhibitor
PDIDD011
Desciclovir
Active compound: Aciclovir triphosphate
Indications: Infection caused by herpesvirus family, including herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, and Epstein-Barr virus (1, 2, 6, 20, 31, 32)
Target: DNA polymerase
PDIDD012
Desogestrel
Active compound: 3-keto-desogestrel
Indications: Contraception
Target: Progesterone receptor, Estrogen receptor
PDIDD013
Dexrazoxane
Active compound: ADR-925
Indications: Cardiomyopathy
Target: Topoisomerase II
PDIDD014
Dextromethorphan
Active compound: Dextrorphan
Indications: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma, cough
Target: Sigma non-opioid intracellular receptor 1; HCG20471, isoform CRA_c; Glutamate receptor ionotropic, NMDA 3A
PDIDD015
DHA-clozapine
Active compound: Clozapine
Indications: Schizophrenia
Target: Dopamine D2 receptor; 5-hydroxytryptamine receptor 2A
PDIDD016
Di Stefano etal_2006_(+)-5
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDD017
Diacerein
Active compound: Rhein
Indications: Osteoarthritis
Target: Interleukin-1 (R1)
PDIDD018
Dibutyrylmorphine
Active compound: Morphine
Indications: Severe pain
Target: na
PDIDD019
Diethylstilbestrol diphosphate
Active compound: Diethylstilbestrol
Indications: Prostate cancer
Target: Estrogen receptor alpha; Estrogen receptor beta
PDIDD020
Diloxanide furoate
Active compound: Diloxanide
Indications: Asymptomatic (cyst passers) intestinal amebiasis; E. histolytica cysts
Target: Protein synthesis
PDIDD021
Dimethyl fumarate
Active compound: Monomethyl fumarate
Indications: Disseminated Sclerosis
Target: na
PDIDD022
Dimethylamine prodrug of stavudine
Active compound: Stavudine
Indications: Tuberculosis
Target: Reverse transcriptase/RnaseH
PDIDD023
Dimethylamino parthenolide
Active compound: Parthenolide
Indications: Leukemia and breast cancer
Target: Transcription factor NF-κB.
PDIDD024
Dipivefrine
Active compound: Epinephrine
Indications: Open-angle glaucoma
Target: Adrenergic receptor
PDIDD025
Dirithromycin
Active compound: 9S-erythromycyclamine
Indications: Bronchitis; Pneumonia; Tonsillitis; Skin infections
Target: 23S-component of the 50S-subunit of prokaryotic ribosomes
PDIDD026
Docarpamine
Active compound: Dopamine
Indications: Refractory ascites
Target: Dopamine receptor D1
PDIDD027
DOPA cyclohexyl ester
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDD028
DOX-FCPPs-PyTPE
Active compound: Doxorubicin
Indications: Breast cancer, Bladder cancer and Cervical cancer
Target: DNA topoisomerase 2-alpha, DNA
PDIDD029
Doxifluridine
Active compound: 5-Fluorouracil
Indications: Stomach cancer; Breast cancer
Target: Thymidylate synthase
PDIDD030
DP-AZT
Active compound: AZT triphosphate
Indications: HIV-AIDS (R1)
Target: HIV-reverse transcriptase and cellular DNA polymerases (Ref 2)
PDIDD031
DP-VPA
Active compound: Valproic acid
Indications: epilepsy, migraine, bipolar, mood, anxiety and psychiatric disorders; cancer, HIV therapy, and neurodegenerative disease
Target: Voltage gated ion channels; HDAC; GABA transaminase; Aldehyde dehydrogenase 5 family member A1
PDIDD032
Droxicam
Active compound: Piroxicam
Indications: Pain and inflammation
Target: Cyclooxygenase (COX)
PDIDD033
Droxidopa
Active compound: Norepinephrine
Indications: Orthostatic dizziness, lightheadedness, or the ‘‘feeling that you are about to black out’’ in adult patients, Parkinsonism
Target: Adrenergic receptor
PDIDD034
DTS-201
Active compound: Doxorubicin
Indications: Breast, colon, prostate, and lung cancers
Target: DNA topoisomerase 2-alpha
PDIDD035
DNR-GA3
Active compound: Daunorubicin (DNR)
Indications: Ovarian cancer
Target: DNA
PDIDD036
DOX-GA3
Active compound: Doxorubicin (DOX)
Indications: Bladder, breast, lung, stomach, and ovarian cancer
Target: DNA