Showing results for 'A'
Total number of hits: 43
Click on results for more details:
PDIDOTH011
3'-Azido-3'-deoxy-5'-O-isonicotinoylthymidine
Active compound: AZT triphosphate
Indications: HIV infection
Target: Reverse Transcriptase
PDIDB031
Butyrylacyclovir
Active compound: Acyclovir
Indications: Herpes simplex virus infections
Target: na
PDIDC028
CHEMBL2063119
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDC029
CHEMBL2079244
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDC031
CHEMBL497111
Active compound: Adamantamine
Indications: Parkinson’s disease (PD)
Target: Glutamate receptor ionotropic, NMDA
PDIDOTH018
5'-MeValPO3(Et) AZT
Active compound: AZT triphosphate
Indications: HIV infection
Target: Reverse Transcriptase
PDIDA001
Abiraterone acetate
Active compound: Abiraterone
Indications: Prostate cancer
Target: 17 α-hydroxylase/C17,20-lyase (CYP17)
PDIDD011
Desciclovir
Active compound: Aciclovir triphosphate
Indications: Infection caused by herpesvirus family, including herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, and Epstein-Barr virus (1, 2, 6, 20, 31, 32)
Target: DNA polymerase
PDIDD013
Dexrazoxane
Active compound: ADR-925
Indications: Cardiomyopathy
Target: Topoisomerase II
PDIDD030
DP-AZT
Active compound: AZT triphosphate
Indications: HIV-AIDS (R1)
Target: HIV-reverse transcriptase and cellular DNA polymerases (Ref 2)
PDIDF015
Fosamprenavir
Active compound: Amprenavir
Indications: HIV infections
Target: HIV Protease
PDIDF016
Fosaprepitant
Active compound: Aprepitant
Indications: Antiemetic; Vomiting and nausea
Target: Neurokinin 1 (NK1) receptor
PDIDH003
Hetacillin
Active compound: Ampicillin
Indications: Bacterial Infections
Target: Penicillin-binding proteins (PBPs) which includes transpeptidases, carboxypeptidases, and endopeptidases
PDIDI011
Isosorbide Diaspirinate
Active compound: Aspirin
Indications: Pain, fever, and inflammation; To inhibit platelet aggregation; myocardial infarction (MI); transient ischemic attacks (TIA); For the prevention of thromboembolism; coronary artery disease (CAD)
Target: Prostaglandin G/H synthase 1; Prostaglandin G/H synthase 2
PDIDI012
Isosorbide nitroaspirin
Active compound: Aspirin
Indications: Pain, fever, and inflammation; To inhibit platelet aggregation; myocardial infarction (MI); transient ischemic attacks (TIA); For the prevention of thromboembolism; coronary artery disease (CAD)
Target: Prostaglandin G/H synthase 1; Prostaglandin G/H synthase 2
PDIDL009
Lenampicillin
Active compound: Ampicillin
Indications: Bacterial infections
Target: Enzyme transpeptidase
PDIDM001
MB07133
Active compound: Ara-CMP
Indications: Myelodysplastic Syndrome; Leukemia; Hepatocellular carcinoma (HCC); liver cancer
Target: AraC triphosphate (araCTP) inhibition of DNA polymerase (By competing with cytidine)
PDIDM009
Mesocarb
Active compound: Amphetamine
Indications: Parkinson’s disease (WL1)
Target: na
PDIDN006
Nepafenac
Active compound: Amfenac
Indications: Pain and inflammation
Target: Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2)
PDIDP018
Pivampicillin
Active compound: Ampicillin
Indications: Respiratory tract infections; Ear, nose and throat infections; Gynecological infections; Urinary tract infections
Target: Enzyme transpeptidase
PDIDA027
Aciclovir
Active compound: Aciclovir triphosphate
Indications: HSV viral infection
Target: DNA polymerase
PDIDP023
Pradefovir
Active compound: Adefovir
Indications: Hepatitis B
Target: Adevofir diphosphate inhibition of RNA-dependent DNA polymerase (By competing with natural dATPs)
PDIDP037
Procarbazine
Active compound: Azoprocarbazine
Indications: Brain tumors and Hodgkin's lymphoma
Target: DNA (alkylating agent)
PDIDA029
Adefovir Dipivoxil
Active compound: Adefovir
Indications: Hepatitis b virus
Target: Reverse transcriptase
PDIDA030
Adenosine
Active compound: Adenosine Monophosphate
Indications: Paroxysmal supraventricular tachycardia (PVST); Narrow-complex supraventricular tachycardias (SVT)
Target: Adenosine receptor
PDIDR012
Retinoyl-AZT
Active compound: AZT triphosphate
Indications: HIV-1
Target: HIV-reverse transcriptase and cellular DNA polymerases
PDIDS002
Sarmoxicillin
Active compound: Amoxicillin
Indications: Na
Target: na
PDIDS010
SCHEMBL15272458
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDS049
Sultamicillin
Active compound: Ampicillin
Indications: Pneumonia and Chronic Obstructive Pulmonary Disease (COPD)
Target: Enzyme transpeptidase
PDIDT006
Tamoxifen
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDA042
ALS-8176
Active compound: ALS-8112
Indications: RSV infection
Target: RSV polymerase
PDIDV001
Valaciclovir
Active compound: Acyclovir
Indications: Herpes Zoster; Suppression of genital herpes lesions in immunocompetent or HIV-infected patients; Cold Sores (Herpes Labialis); Chickenpox
Target: HSV-specified DNA polymerases
PDIDZ001
Zidovudine prodrug
Active compound: AZT triphosphate
Indications: HIV infection
Target: DNA polymerase
PDIDC114
Cytarabine
Active compound: Ara-CTP
Indications: Acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma
Target: DNA, DNA Polymerase
PDIDA062
Astarabine
Active compound: Ara-CTP
Indications: Acute myeloid leukemia (AML)
Target: DNA, DNA Polymerase
PDIDA045
Amfetaminil
Active compound: Amphetamine
Indications: Fatigue, Depression, potency disorders, Narcolepsy, childhood hyperkinesis
Target: Synaptic vesicular amine transporter; Sodium-dependent dopamine transporter
PDIDA054
Aniline mustard glucuronide
Active compound: Aniline mustard
Indications: Colon cancer
Target: Beta-glucuronidase-positive cells
PDIDA057
Aripiprazole cavoxil
Active compound: Aripiprazole
Indications: bipolar disorder
Target: Dopamine receptor
PDIDA058
Aripiprazole lauroxil
Active compound: Aripiprazole
Indications: Schizophrenia; senile dementia; transient psychosis following surgery; or Myocardial infaraction
Target: Dopamine D2 receptor; 5-hydroxytryptamine receptor 1A; 5-hydroxytryptamine receptor 2A
PDIDA063
Atovaquone prodrug
Active compound: Atovaquone
Indications: Pneumocystis carinii infection
Target: Cytochrome bc1 complex (Complex III)
PDIDA066
Azilsartan Medoxomil
Active compound: Azilsartan
Indications: Essential hypertension
Target: Type-1 angiotensin II receptor
PDIDB001
Bacampicillin
Active compound: Ampicillin
Indications: Bacterial infections
Target: Enzyme transpeptidase
PDIDB005
Banoxantrone
Active compound: AQ4
Indications: Tumor
Target: Topoisomerase II