Showing results for 'Solubility'
Total number of hits: 89
Click on results for more details:
PDIDOTH011
3'-Azido-3'-deoxy-5'-O-isonicotinoylthymidine
Active compound: AZT triphosphate
Indications: HIV infection
Target: Reverse Transcriptase
PDIDB030
Brivanib alaninate
Active compound: BMS-540215
Indications: Hepatocellular cancer
Target: VEGFR-2/FGFR-1 kinase inhibitor
PDIDC004
Canrenoate
Active compound: Canrenone
Indications: Hypertension (R1)
Target: Mineralocorticoid receptor
PDIDC021
Ceftobiprole medocaril
Active compound: Ceftobiprole
Indications: Hospital-acquired pneumonia (HAP) and community-acquired pneumonia (CAP)
Target: Penicillin-binding proteins (PBPs)
PDIDC024
CEP-7055
Active compound: CEP-5214
Indications: Brain tumors and colon carcinoma
Target: Pan vascular endothelial growthfactors (VEGF) kinase
PDIDC025
CHEMBL1205526
Active compound: Triapine
Indications: Lung carcinoma
Target: Ribonucleotide reductase
PDIDC027
CHEMBL1802093
Active compound: DOPAC
Indications: Lung, ovary and breast cancer
Target: Tyrosine kinases
PDIDOTH015
4-phenylbutyrate
Active compound: Phenylacetate
Indications: Cystic fibrosis (WL2); hyperammonemia (R1)
Target: Histone deacetylase (WL2)
PDIDC040
Chloramphenicol succinate
Active compound: Chloramphenicol
Indications: Typhoid fever, salmonella septicaemia
Target: 50S ribosomal subunit
PDIDOTH018
5'-MeValPO3(Et) AZT
Active compound: AZT triphosphate
Indications: HIV infection
Target: Reverse Transcriptase
PDIDC064
CID 132564392
Active compound: SN-38
Indications: Cancer
Target: DNA topoisomerase I inhibitor
PDIDC065
CID 132564393
Active compound: SN-38
Indications: Cancer
Target: DNA topoisomerase I inhibitor
PDIDOTH019
9-ACG
Active compound: 9-AC
Indications: Cancer
Target: Beta-glucuronidase-positive cells
PDIDC089
Cidofovir
Active compound: Cidofovir diphosphate
Indications: Cytomegalovirus (CMV)
Target: Viral DNA
PDIDA002
AC1L9V0Z
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDC095
ClNH3MeCOO Echinocandin
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDC100
Clorazepate
Active compound: Nordazepam
Indications: Epilepsy
Target: GABA-A receptors
PDIDA003
AC1L9V12
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDC108
Combretastatin A1 bis(phosphate)
Active compound: Combretastatin A1
Indications: Thyroid cancer
Target: Tubulin
PDIDC109
CTK6A1633
Active compound: TAK-456
Indications: Pulmonary aspergillosis
Target: na
PDIDA004
AC1L9V15
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDD006
DC-81 prodrug
Active compound: DC-81
Indications: Cancer
Target: DNA minor groove
PDIDA005
AC1L9WBZ
Active compound: Lamivudine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDD019
Diethylstilbestrol diphosphate
Active compound: Diethylstilbestrol
Indications: Prostate cancer
Target: Estrogen receptor alpha; Estrogen receptor beta
PDIDA006
AC1L9WC2
Active compound: Lamivudine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDD023
Dimethylamino parthenolide
Active compound: Parthenolide
Indications: Leukemia and breast cancer
Target: Transcription factor NF-κB.
PDIDD028
DOX-FCPPs-PyTPE
Active compound: Doxorubicin
Indications: Breast cancer, Bladder cancer and Cervical cancer
Target: DNA topoisomerase 2-alpha, DNA
PDIDA007
AC1L9WC5
Active compound: Lamivudine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDA008
AC1L9WC8
Active compound: Lamivudine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDE011
Estradiol acetate
Active compound: Estradiol
Indications: Vasomotor and urogenital symptoms associated with menopause
Target: Estrogen Receptor (ER) including ERα and ERβ subtypes
PDIDA009
AC1L9WCB
Active compound: FTC
Indications: HIV infection
Target: Reverse Transcriptase
PDIDE020
Estriol sulfate glucuronide
Active compound: Estriol
Indications: Na
Target: na
PDIDA010
AC1L9WCE
Active compound: FTC
Indications: HIV infection
Target: Reverse Transcriptase
PDIDF005
Fenofibrate
Active compound: Fenofibric acid
Indications: Primary hypercholesterolemia or mixed dyslipidemia; Hypertriglyceridemia (KEGG)
Target: Peroxisome proliferator-activated receptor alpha
PDIDF009
Fludarabine
Active compound: Fludarabine triphosphate
Indications: B-cell chronic lymphocytic leukemia
Target: Ribonucleoside-diphosphate reductase subunit M1; DNA polymerase; cytosolic 5′-nucleotidase II
PDIDA011
AC1LA7FB
Active compound: KNI-279
Indications: HIV infection
Target: HIV Protease
PDIDF017
Fosbretabulin
Active compound: Combretastatin A4
Indications: Thyroid cancer
Target: Tubulin
PDIDF019
Fosfluconazole
Active compound: Fluconazole
Indications: 1) Vaginal yeast infections caused by Candida 2) Systemic Candida infections 3) Both esophageal and oropharyngeal candidiasis 4) Cryptococcal meningitis 5) UTI (urinary tract infection) by Candida 6) Peritonitis (inflammation of the peritoneum) caused by Candida
Target: Sterol 14alpha-demethylase (KEGG)
PDIDA012
AC1LAEL0
Active compound: KNI-225
Indications: HIV infection
Target: HIV Protease
PDIDF022
Fosphenytoin
Active compound: Phenytoin
Indications: Epilepsy
Target: Sodium channel protein type 5 subunit alpha
PDIDF023
Fospropofol
Active compound: Propofol
Indications: General anesthesia
Target: GABAA receptor
PDIDF025
Fostemsavir
Active compound: Temsavir
Indications: HIV-1
Target: gp120 molecule on Virus surface (Ref 1)
PDIDG010
GW5634
Active compound: GW8248
Indications: HIV infection
Target: HIV-1 non-nucleoside reversetranscriptase inhibitors (NNRTIs)
PDIDH007
HOOCEtNHCOO Echinocandin
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDH008
HOOCMeNHCOO Echinocandin
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDH009
HOOCMeNMeCOO Echinocardin
Active compound: Echinocandin B
Indications: Pneumocystis carinii pneumonia
Target: na
PDIDI008
Isavuconazonium
Active compound: Isavuconazole
Indications: Invasive aspergillosis and Invasive mucormycosis
Target: lanosterol 14-alpha-demethylase (Ref 1); cytochrome P450 3A4 (CYP3A4/5) (Ref 2)
PDIDA017
AC1LANX6
Active compound: KNI-227
Indications: HIV infection
Target: HIV Protease
PDIDL014
Lisdexamfetamine
Active compound: D-amphetamine
Indications: Attention Deficit Disorder With Hyperactivity (ADHD); Binge Eating Disorder (BED)
Target: Trace amine-associated receptor 1 (Drug Bank); Alpha-1B adrenergic receptor (Therapeutic Target Database)
PDIDM004
Melevodopa
Active compound: Levodopa
Indications: Parkinson’s disease (R2, R3)
Target: Dopamine receptors
PDIDM021
Minnelide
Active compound: Triptolide
Indications: Pancreatic cancer; Neuroblastoma; Breast cancer; Prostate cancer
Target: ATPase
PDIDOTH004
125IQ2-P
Active compound: 125IQ2-OH
Indications: Cancer
Target: na
PDIDM028
Molsidomine
Active compound: Linsidomine
Indications: Ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension
Target: Hyperpolarizes cell membrane
PDIDN013
NSC-606698
Active compound: Rapamycin
Indications: Diabetes mellitus, asthma and rheumatic disorders
Target: na
PDIDP001
P1-185
Active compound: Progesterone
Indications: Traumatic brain injury (TBI)
Target: na
PDIDP007
Parecoxib
Active compound: Valdecoxib
Indications: Antiinflammatory; To reduce post-operative pain
Target: Cyclooxygenase-2 (COX-2)
PDIDP008
PBBG (Pyrrolo[2,1-c][1,4]-benzodiazepine-beta-glucuronide)
Active compound: NSC718813
Indications: Solid tumors
Target: DNA minor groove
PDIDA026
Acetyl sulfisoxazole
Active compound: Sulfisoxazole
Indications: Urinary tract infections
Target: Dihydropteroate synthase
PDIDP021
PR-104
Active compound: PR-104M
Indications: Solid tumors, Lung cancer, And leukemia
Target: DNA
PDIDP025
Prednisolone phosphate
Active compound: Prednisolone
Indications: Allergic and inflammatory conditions
Target: Glucocorticoid receptor
PDIDP026
Prednisolone tetrahydrophthalate
Active compound: Prednisolone
Indications: Allergic and inflammatory conditions
Target: Glucocorticoid receptor
PDIDP043
Propacetamol
Active compound: Paracetamol
Indications: Pain and fever
Target: Prostaglandin G/H synthase 1; Cannabinoid receptor 1; Prostaglandin G/H synthase 2
PDIDP045
Psilocybin
Active compound: Psilocin
Indications: Psychological disorder
Target: 5-HT2A, 5-HT2C and 5-HT1A
PDIDP048
Pyridoxine
Active compound: pyridoxal 5-phosphate
Indications: For the treatment of vitamin B6 deficiency and for the prophylaxis of Isoniazid-induced peripheral neuropathy
Target: Pyridoxal kinase
PDIDQ001
Quercetin
Active compound: DOPAC
Indications: Lung, ovary and breast cancer
Target: Tyrosine kinases
PDIDQ001
Quercetin
Active compound: 3-Hydroxyphenylacetic acid
Indications: Lung, ovary and breast cancer
Target: Tyrosine kinases
PDIDR014
Rilmazafone
Active compound: M-4
Indications: Insomnia
Target: GABA receptors
PDIDS004
SCHEMBL10193041
Active compound: SN-38
Indications: Cancer
Target: DNA topoisomerase I inhibitor
PDIDS011
SCHEMBL156939
Active compound: Testosterone
Indications: Osteoporosis, maintain normal muscle and bonemass, erythropoiesis, and sexual function
Target: na
PDIDA034
Alalevonadifloxacin
Active compound: Levonadifloxacin
Indications: Acute bacterial skin and skin structure infections (ABSSSI)
Target: DNA gyrase
PDIDS027
SCHEMBL6940322
Active compound: TAK-456
Indications: Aspergillosis
Target: na
PDIDS029
SCHEMBL8504774
Active compound: L014097
Indications: Depression
Target: Non-peptide NK1 neurokinin receptor
PDIDS034
SF1126
Active compound: LY294002/SF1101
Indications: Metastatic Solid Tumors / Cancers / Solid Cancers
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
PDIDS035
SF1326
Active compound: LY294002/SF1101
Indications: Metastatic Solid Tumors / Cancers / Solid Cancers
Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
PDIDA036
Alatrofloxacin
Active compound: Trovafloxacin
Indications: Broad spectrum antibiotic
Target: DNA gyrase and DNA topoisomerase IV activities
PDIDS040
SNX-5422
Active compound: SNX-2112
Indications: Breast, lung, and ovarian cancer
Target: Heat shock protein HSP 90
PDIDT003
Taleghani_etal_2017_parthabine
Active compound: Parthenolide
Indications: Cancer
Target: STAT mediated gene transcription and NF-kB mediated gene transcription
PDIDT004
Taleghani_etal_2017_parthalan
Active compound: Parthenolide
Indications: Cancer
Target: STAT mediated gene transcription and NF-kB mediated gene transcription
PDIDT013
Teglarinad
Active compound: GMX1778
Indications: Chronic lymphocytic leukemia, acute leukemia,and high-grade lymphomas
Target: Nicotinamide phosphoribosyl transferase
PDIDA040
Allopurinol
Active compound: Oxypurinol
Indications: Chronic gout
Target: Xanthine oxidase
PDIDT042
Trestolone acetate
Active compound: 19-nortestosterone
Indications: To promoting muscle growth in cattle
Target: Androgen receptor; progesterone receptor (ref 1)
PDIDX002
XMT-1001
Active compound: camptothecin
Indications: Tumor
Target: DNA topoisomerase I
PDIDD035
DNR-GA3
Active compound: Daunorubicin (DNR)
Indications: Ovarian cancer
Target: DNA
PDIDA058
Aripiprazole lauroxil
Active compound: Aripiprazole
Indications: Schizophrenia; senile dementia; transient psychosis following surgery; or Myocardial infaraction
Target: Dopamine D2 receptor; 5-hydroxytryptamine receptor 1A; 5-hydroxytryptamine receptor 2A
PDIDA060
Artesunate
Active compound: Dihydroartemisinin
Indications: Malaria
Target: Malaria proteins EXP1
PDIDA063
Atovaquone prodrug
Active compound: Atovaquone
Indications: Pneumocystis carinii infection
Target: Cytochrome bc1 complex (Complex III)
PDIDA064
Avizafone
Active compound: Diazepam
Indications: Anxiolytic agent and muscle relaxant,premediation for anesthesia, a sedative for minor surgery or invasive procedures, and for treatment of status epileptus or severe recurrent seizures
Target: Acetylcholinesterase
PDIDB013
Besifovir
Active compound: LB80317
Indications: Hepatitis B(HBV) infection
Target: Tissue
PDIDB014
Bezitramide
Active compound: Despropionyl-bezitramide
Indications: Severe chronic pain
Target: na