Showing results for 'Membrane permeability'
Total number of hits: 53
Click on results for more details:
PDIDOTH013
4-Chlorokynurenine
Active compound: 7-chlorokynurenic acid
Indications: Prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma
Target: N-methyl-D-aspartate (NMDA) receptor
PDIDC031
CHEMBL497111
Active compound: Adamantamine
Indications: Parkinson’s disease (PD)
Target: Glutamate receptor ionotropic, NMDA
PDIDC032
CHEMBL497112
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC033
CHEMBL590229
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC034
CHEMBL598828
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC035
CHEMBL598829
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC043
CID 10009229
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC044
CID 10089832
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC045
CID 101239087
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC046
CID 101239088
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC047
CID 101239089
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC048
CID 101239091
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC049
CID 101239092
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC051
CID 101681216
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC052
CID 101681217
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC053
CID 101681218
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC054
CID 102239065
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC056
CID 10621768
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC057
CID 10937253
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC058
CID 11796118
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC060
CID 129866160
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDC061
CID 129866166
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDC062
CID 129866179
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDC063
CID 129866181
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDC069
CID 21426279
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDD015
DHA-clozapine
Active compound: Clozapine
Indications: Schizophrenia
Target: Dopamine D2 receptor; 5-hydroxytryptamine receptor 2A
PDIDD031
DP-VPA
Active compound: Valproic acid
Indications: epilepsy, migraine, bipolar, mood, anxiety and psychiatric disorders; cancer, HIV therapy, and neurodegenerative disease
Target: Voltage gated ion channels; HDAC; GABA transaminase; Aldehyde dehydrogenase 5 family member A1
PDIDG011
Gynther_etal_2010_Ketoprofen-L-lysine
Active compound: Ketoprofen
Indications: Acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain
Target: Cyclooxygenase-2 (COX-2)
PDIDI005
Imipramine
Active compound: Desipramine
Indications: Depression
Target: Noradrenaline transporter (NET) reuptake inhibitor
PDIDK001
Ketoprofen-L-tyrosine
Active compound: Ketoprofen
Indications: Acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain
Target: Cyclooxygenase-2 (COX-2)
PDIDL011
Levodopa
Active compound: Dopamine
Indications: Parkinson's disease and dopamine-responsive dystonia
Target: Dopamine receptor D1, D2, D3, D4, D5 (WL 3)
PDIDA021
Aceburic acid
Active compound: Gamma-hydroxybutyrate
Indications: Anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
Target: Cell specific
PDIDM027
Moexipril
Active compound: Moexiprilat
Indications: Hypertension and congestive heart failure
Target: Angiotensin-converting-enzyme
PDIDP013
Perindopril
Active compound: Perindoprilat
Indications: Hypertension
Target: Angiotensin-converting-enzyme
PDIDP016
Picamilon
Active compound: GABA
Indications: Migraine, neuro infections, senile psychosis, certain types of glaucoma, and even acute alcohol intoxication
Target: GABA-A and GABA-B
PDIDR007
RB150
Active compound: EC33
Indications: Blood Pressure
Target: Aminopeptidase A (APA)
PDIDR012
Retinoyl-AZT
Active compound: AZT triphosphate
Indications: HIV-1
Target: HIV-reverse transcriptase and cellular DNA polymerases
PDIDR015
Risperidone
Active compound: Paliperidone
Indications: Schizophrenia and related disorders
Target: P-glycoprotein-mediated transport; 5-hydroxytryptamine (5-HT)2A, dopamine D2 and α1- and α2-adrenergic receptors
PDIDA032
AKOS024372695
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS009
SCHEMBL14764340
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS012
SCHEMBL18259288
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS014
SCHEMBL19730390
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS015
SCHEMBL19730392
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS016
SCHEMBL19730393
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS017
SCHEMBL19730395
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS018
SCHEMBL19730396
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS019
SCHEMBL19730397
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS020
SCHEMBL19730398
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS021
SCHEMBL19730400
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: GABA-benzodiazepine receptor (GABA-BZR) complex
PDIDS038
Simvastatin
Active compound: Simvastatin acid
Indications: Dyslipidemia, elevated lipid levels
Target: 3-hydroxy-3-methylglutaryl (HMG) coenzyme reductase
PDIDT015
Telotristat etiprate
Active compound: Telotristat
Indications: Carcinoid syndrome and diarrhea (R1)
Target: Tryptophan hydroxylase [TPH1 and TPH2] (R1, R2)
PDIDV004
Valofan
Active compound: Proxibarbital
Indications: Na
Target: na
PDIDA059
Artemisinin
Active compound: Dihydroartemisinin
Indications: Malaria
Target: Heme present in the hemozoin and hemoglobin; histidine-rich protein II (PfHRP II)