Showing results for 'Target/Cell specificity'
Total number of hits: 92
Click on results for more details:
PDIDOTH001
(South)-Methanocarba-Thymidine
Active compound: Thymidine
Indications: Hepatitis b virus (hbv) infection
Target: Thymidine kinase
PDIDB016
Bis(3-PentylOC)PMPA
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDB017
Bis(EthylOC)PMPA
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDB018
Bis(NeopentylOC)PMPA
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDB019
Bis(t-ButylOC)PMPA
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDC003
Canfosfamide
Active compound: Bis[bis(2-chloroethyl)amino]phosphinate
Indications: Colon and breast carcinoma
Target: DNA
PDIDC005
Capecitabine
Active compound: Fluorouracil
Indications: Candida or Cryptococcus neoformans fungal infections
Target: Thymidylate synthase (TS); DNA; RNA
PDIDC010
Cbz–Ser–Ser–Phe–Tyr linked prodrug of 4-aminocylophosphamide
Active compound: Phosphoramide mustard
Indications: Prostate cancer
Target: na
PDIDC036
CHEMBL62755
Active compound: Phenylmethaneselenol
Indications: Kidney cancer
Target: na
PDIDOTH016
4-S-Cysteaminylphenol
Active compound: DTXSID30473723
Indications: Malignant melanoma
Target: Thymidylate synthase and DNA synthesis
PDIDOTH017
5-FP
Active compound: 5-FU
Indications: liver, lung, adrenal, testis, and prostate cancers
Target: Thymidylate synthase
PDIDC110
CTK6D3437
Active compound: FTC
Indications: HIV infection
Target: Reverse Transcriptase
PDIDD003
Dacarbazine
Active compound: 5-Aminoimidazole-4-Carboxamide
Indications: malignant melanoma, Hodgkin's lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
Target: na
PDIDD004
D-alanine
Active compound: Hydrogen peroxide
Indications: Cancer
Target: DNA, Proteins and Lipids
PDIDD007
D-Deprenyl
Active compound: D-amphetamine
Indications: Attention deficit disorder, hyperactivity and narcolepsy
Target: na
PDIDD028
DOX-FCPPs-PyTPE
Active compound: Doxorubicin
Indications: Breast cancer, Bladder cancer and Cervical cancer
Target: DNA topoisomerase 2-alpha, DNA
PDIDD029
Doxifluridine
Active compound: 5-Fluorouracil
Indications: Stomach cancer; Breast cancer
Target: Thymidylate synthase
PDIDD034
DTS-201
Active compound: Doxorubicin
Indications: Breast, colon, prostate, and lung cancers
Target: DNA topoisomerase 2-alpha
PDIDA054
EO9
Active compound: Hydroquinone form of EO9
Indications: Breast and lung cancer
Target: DNA minor grove
PDIDE005
Epirubicin-glucuronide
Active compound: Epirubicin
Indications: Cancer
Target: Topoisomerase II
PDIDE025
Evofosfamide
Active compound: Bromo-isophosphoramide
Indications: Solid tumors
Target: DNA
PDIDF003
Favipiravir
Active compound: Favipiravir riboside triphosphate
Indications: Influenza
Target: viral RNA polymerase
PDIDF004
F-dAdo
Active compound: 2-Fluoroadenine
Indications: Tumors
Target: Purine nucleoside phosphorylase DeoD-type
PDIDF006
Fesoterodine
Active compound: 5-hydroxymethyltolterodine
Indications: Urinary incontinence
Target: M2 and M3 muscarinic receptors
PDIDF008
Flucytosine
Active compound: 5-Fluorouridine 5'-triphosphate
Indications: Candida or Cryptococcus neoformans fungal infections
Target: DNA
PDIDF014
Fmoc-Lys(Ac)-Puromycin
Active compound: Puromycin
Indications: Cancer
Target: 60S ribosomal protein
PDIDF021
Fosnetupitant
Active compound: Netupitant
Indications: Acute and delayed nausea and vomiting associated with moderately emetogenic cancer chemotherapy; acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy
Target: Neurokinin-1 (NK-1) receptors
PDIDA013
AC1LAHXM
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDG002
Gamma-Ghb
Active compound: DTXSID10952728
Indications: Malignant melanoma
Target: Thymidylate synthase and DNA synthesis
PDIDA014
AC1LAHXP
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDH002
Heroin
Active compound: Morphine
Indications: Pain
Target: μ-opioid receptors
PDIDA015
AC1LAHXS
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDI009
Isoniazid
Active compound: Isonicotinic Acyl redical
Indications: Tuberculosis (TB)
Target: Enoyl-acyl carrier protein reductase (inha); Catalase-peroxidase
PDIDA016
AC1LAHZV
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDL001
L-377202
Active compound: Leurubicin
Indications: Prostate cancer
Target: na
PDIDL001
L-377202
Active compound: Doxorubicin
Indications: Prostate cancer
Target: na
PDIDL004
Lansoprazole
Active compound: Sulfenamide form of Lansoprazole
Indications: Erosive reflux oesophagitis, active gastric ulcer, active duodenal ulcer, tuberculosis
Target: (H+,K+)-ATPase
PDIDL005
Latanoprost
Active compound: Latanoprost acid
Indications: Open-angle glaucoma or ocular hypertension; intraocular pressure as a result of angle-closure glaucoma
Target: Prostaglandin F2-alpha receptor
PDIDA018
AC1MHEO9
Active compound: 2-Amino-6-methoxypurine analogue
Indications: Cytomegalo Virus Infection
Target: DNA
PDIDM001
MB07133
Active compound: Ara-CMP
Indications: Myelodysplastic Syndrome; Leukemia; Hepatocellular carcinoma (HCC); liver cancer
Target: AraC triphosphate (araCTP) inhibition of DNA polymerase (By competing with cytidine)
PDIDM002
MB07811
Active compound: MB07344
Indications: Hyperlipidemia
Target: Thyroid hormone receptor beta
PDIDA019
AC1NUIF5
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDM005
Menadione
Active compound: Semiquinone radical
Indications: iver, colon, lung, stomach, and prostateand leukemia
Target: DNA
PDIDM006
MeP-dR
Active compound: 6-Methylpurine
Indications: Tumors
Target: Purine nucleoside phosphorylase DeoD-type
PDIDA020
AC1NUIZT
Active compound: PMPA
Indications: HIV infection
Target: Reverse Transcriptase
PDIDM017
Methyl aminolevulinate
Active compound: Protoporphyrin IX
Indications: Actinic keratosis (R1)
Target: High affinity immunoglobulin gamma Fc receptor I (WL2)
PDIDM019
Mevastatin
Active compound: Hydroxy acid form of Mevastatin
Indications: Bacterial Infections
Target: HMG-CoA reductase
PDIDM024
Mipsagargin
Active compound: Thapsigargin
Indications: Tumor and Cancer
Target: Prostate-specificmembrane antigen (PSMA)
PDIDM025
Mitomycin C
Active compound: Quinone Methide
Indications: Breast, stomach, esophagus, bladder and non-small cell lung cancer
Target: DNA minor grove
PDIDN006
Nepafenac
Active compound: Amfenac
Indications: Pain and inflammation
Target: Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2)
PDIDN016
NSC643812
Active compound: Combretastatin
Indications: cancer
Target: Tubulin
PDIDN017
NSC-731657
Active compound: STAVUDINE
Indications: HIV infection
Target: Reverse Transcriptase
PDIDN018
NSC-731658
Active compound: STAVUDINE
Indications: HIV infection
Target: Reverse Transcriptase
PDIDO005
Omeprazole
Active compound: Sulfenamide form of Omeprazole
Indications: Peptic ulcers, zollinger–ellison syndrome, erosive reflux oesophagitis; gastric ulcers
Target: (H+,K+)-ATPase
PDIDO010
Oxycodone
Active compound: Oxymorphone
Indications: Moderate to moderately severe acute or chronic pain.
Target: κ-opioid receptors
PDIDA025
Acetadote
Active compound: L-cysteine
Indications: HIV infection
Target: Glutathione synthetase; Cystine/glutamate transporter
PDIDP005
Pantoprazole
Active compound: Sulfenamide form of Pantoprazole
Indications: Erosive esophagitis associated with gastroesophageal reflux disease (gerd)
Target: (H+,K+)-ATPase
PDIDP006
Paracetamol
Active compound: N-arachidonoylphenolamine
Indications: Pain and fever.
Target: Cyclooxygenase (COX), TRPA1-receptors
PDIDP009
PD1
Active compound: Levofloxacin
Indications: Acute bacterial sinusitis, pneumonia, urinary tract infections, chronic prostatitis, traveler's diarrhea, tuberculosis, and plague and some types of gastroenteritis
Target: Cell specific
PDIDP010
PD2
Active compound: Levofloxacin
Indications: Urinary tract infection and Pneumonia
Target: Cell specific
PDIDP012
Peptide-doxorubicin prodrug
Active compound: Doxorubicin
Indications: Tumor
Target: na
PDIDP021
PR-104
Active compound: PR-104M
Indications: Solid tumors, Lung cancer, And leukemia
Target: DNA
PDIDP022
PR-104A
Active compound: PR-104M
Indications: Solid tumors, Lung cancer, And leukemia
Target: DNA
PDIDP038
Progabide
Active compound: SL-75102
Indications: Epilepsy
Target: GABAA, GABAB, and GABAA-ρ receptors
PDIDA029
Adefovir Dipivoxil
Active compound: Adefovir
Indications: Hepatitis b virus
Target: Reverse transcriptase
PDIDR004
Rabeprazole
Active compound: Sulfenamide form of Rabeprazole
Indications: Erosive esophagitis associated with gastroesophageal reflux disease (gerd)
Target: na
PDIDR010
Rescula
Active compound: Unoprostone
Indications: Occular Hypertension
Target: na
PDIDR016
Ro-48-3656
Active compound: Ro 44-3888
Indications: Acute coronary syndrome
Target: Fibrinogen receptor; GP IIb-IIIa receptor
PDIDR019
Ropidoxuridine
Active compound: Idoxuridine
Indications: Radiosensitizer
Target: Thymidylate synthase
PDIDS003
SB 204990
Active compound: SB 201076
Indications: Hypolipidaemia
Target: ATP citrate (pro-S)-lyase
PDIDA033
Alacepril
Active compound: Captopril
Indications: Hypertension and congestive heart failure
Target: Angiotensin-converting-enzyme inhibitor
PDIDS022
SCHEMBL4047434
Active compound: Eniluracil
Indications: liver, lung, adrenal, testis, and prostate cancers
Target: Mechanism-based inhibitor of dihy-dropyrimidine dehydrogenase (DPD)
PDIDS026
SCHEMBL6711678
Active compound: 6-Mercaptopurine
Indications: Colon and breast carcinoma
Target: DNA
PDIDS036
Sibrafiban
Active compound: Ro 44-3888
Indications: Acute coronary syndrome
Target: Fibrinogen receptor; GP IIb-IIIa receptor
PDIDS040
SNX-5422
Active compound: SNX-2112
Indications: Breast, lung, and ovarian cancer
Target: Heat shock protein HSP 90
PDIDA037
Aldoxorubicin
Active compound: Doxorubicin
Indications: Solid tumors
Target: DNA topoisomerase 2-alpha
PDIDT012
Tegafur
Active compound: 5-Fluorouracil
Indications: Candida or Cryptococcus neoformans fungal infections
Target: Thymidylate Synthase (TS)
PDIDT017
Temozolomide
Active compound: 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC)
Indications: Brain cancers, astrocytoma, glioblastoma multiforme
Target: DNA (alkylating agent)
PDIDT022
Testifenon
Active compound: Dihydrotestosterone
Indications: Tumor and Cancer
Target: Androgen receptor
PDIDT029
Thymectacin
Active compound: Brivudine monophosphate
Indications: Tumours
Target: Thymidylate synthase (ts)
PDIDT029
Thymectacin
Active compound: Brivudine
Indications: Colorectal cancer
Target: Thymidylate synthase
PDIDT033
Tirapazamine
Active compound: Benzotriazinyl radicals
Indications: Breast and lung cancer
Target: DNA minor grove
PDIDT035
Tolterodine
Active compound: 5-Hydroxymethyltolterodine (5-HMT)
Indications: Urinary incontinence
Target: M2 and M3 muscarinic receptors
PDIDT038
Travoprost
Active compound: Travoprost free acid
Indications: Glaucoma or ocular hypertension
Target: FP prostanoid receptor
PDIDV010
VX-765
Active compound: VRT-043198
Indications: Inflamation, Psoriasis and psoriatic disorders
Target: ICE/caspase-1 sub-family caspases
PDIDZ001
Zidovudine prodrug
Active compound: AZT triphosphate
Indications: HIV infection
Target: DNA polymerase
PDIDA046
Amifostine
Active compound: WR-1065
Indications: Cytoprotective adjuvant used in cancer
Target: na
PDIDA054
Aniline mustard glucuronide
Active compound: Aniline mustard
Indications: Colon cancer
Target: Beta-glucuronidase-positive cells
PDIDA055
Apaziquone
Active compound: Semi-quinone radical form of EO9
Indications: Breast and lung cancer
Target: DNA minor grove
PDIDOTH008
2,4-Dopa
Active compound: 6-Hydroxydopa
Indications: Malignant melanoma
Target: DNA, RNA, and protein synthesis
PDIDB002
Baloxavir marboxil
Active compound: Baloxavir
Indications: Influenza
Target: Polymerase acidic (PA) protein found in influenza virus
PDIDB005
Banoxantrone
Active compound: AQ4
Indications: Tumor
Target: Topoisomerase II