Showing results for 'Bioavailibility'
Total number of hits: 135
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PDIDOTH010
3,4-Dibenzoyl dopamine
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB021
Bodor et al_08
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB022
Bodor et al_09
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB023
Bodor et al_10
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB024
Bodor et al_11
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB029
Brincidofovir
Active compound: Cidofovir
Indications: Infection with human cytomegalovirus; Adenovirus
Target: Cytomegalovirus (CMV) DNA Polymerase
PDIDB030
Brivanib alaninate
Active compound: BMS-540215
Indications: Hepatocellular cancer
Target: VEGFR-2/FGFR-1 kinase inhibitor
PDIDC001
Candesartan Cilexetil
Active compound: Candesartan
Indications: Hypertension
Target: Angiotensin ii receptor
PDIDC005
Capecitabine
Active compound: Fluorouracil
Indications: Candida or Cryptococcus neoformans fungal infections
Target: Thymidylate synthase (TS); DNA; RNA
PDIDC006
Carfecillin
Active compound: Carbenicillin
Indications: Chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
Target: Penicillin binding protein
PDIDC007
Carindacillin
Active compound: Carbenicillin
Indications: Gram-negative bacterial infection
Target: Penicillin-sensitive transpeptidase c-terminal domain
PDIDC012
CDP323
Active compound: Zaurategrast
Indications: Multiple sclerosis (MS)
Target: Integrin alpha-4
PDIDC016
Cefotiam hexetil
Active compound: Cefotiam
Indications: Surgical infection, postoperative infections, bacterial septicaemia, bone and joint infections, cholangitis, cholecystitis, peritonitis, prostatitis, pyelonephritis, respiratory tract infections, skin and soft tissue infections, cystitis, urethritis, and infections caused by susceptible organisms
Target: Penicillin binding protein 1A. 1B and 3 of E. Coli
PDIDC026
CHEMBL1615593
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC029
CHEMBL2079244
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDC033
CHEMBL590229
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC034
CHEMBL598828
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC035
CHEMBL598829
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC041
Chlorotrianisene
Active compound: Triphenylethylene
Indications: Hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias
Target: Estrogen receptor
PDIDC050
CID 101458753
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC059
CID 12004257
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC068
CID 21390763
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC072
CID 71763696
Active compound: SCHEMBL5341592
Indications: P. aeruginosa
Target: na
PDIDC073
CID 72191181
Active compound: SCHEMBL14517194
Indications: P. aeruginosa
Target: na
PDIDC074
CID 73317165
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC077
CID 75242292
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC078
CID 75242294
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC079
CID 75243316
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC080
CID 75243318
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC081
CID 75243320
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC082
CID 75243324
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC083
CID 75243326
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC084
CID 76723249
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC085
CID 76723253
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC086
CID 76723259
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC088
CID 86157027
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDC090
Cilazapril
Active compound: Cilazaprilat
Indications: Hypertension and heart failure
Target: Angiotensin-converting enzyme (ace)
PDIDD001
Dabigatran Etexilate
Active compound: Dabigatran
Indications: Anticoagulant
Target: Prothrombin
PDIDD005
Dasolampanel
Active compound: Tezampanel
Indications: Migraine
Target: AMPA- and KA-subtype ionotropic Glu receptors
PDIDD010
Delapril
Active compound: 5-hydroxydelapril diacid
Indications: Hypertension and heart failure
Target: Converting enzyme inhibitor (CEI); ACE inhibitor
PDIDD010
Delapril
Active compound: Delapril diacid
Indications: Hypertension and heart failure
Target: Converting enzyme inhibitor (CEI); ACE inhibitor
PDIDD011
Desciclovir
Active compound: Aciclovir triphosphate
Indications: Infection caused by herpesvirus family, including herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, and Epstein-Barr virus (1, 2, 6, 20, 31, 32)
Target: DNA polymerase
PDIDD012
Desogestrel
Active compound: 3-keto-desogestrel
Indications: Contraception
Target: Progesterone receptor, Estrogen receptor
PDIDD016
Di Stefano etal_2006_(+)-5
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDD017
Diacerein
Active compound: Rhein
Indications: Osteoarthritis
Target: Interleukin-1 (R1)
PDIDD019
Diethylstilbestrol diphosphate
Active compound: Diethylstilbestrol
Indications: Prostate cancer
Target: Estrogen receptor alpha; Estrogen receptor beta
PDIDD020
Diloxanide furoate
Active compound: Diloxanide
Indications: Asymptomatic (cyst passers) intestinal amebiasis; E. histolytica cysts
Target: Protein synthesis
PDIDD027
DOPA cyclohexyl ester
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDD030
DP-AZT
Active compound: AZT triphosphate
Indications: HIV-AIDS (R1)
Target: HIV-reverse transcriptase and cellular DNA polymerases (Ref 2)
PDIDD033
Droxidopa
Active compound: Norepinephrine
Indications: Orthostatic dizziness, lightheadedness, or the ‘‘feeling that you are about to black out’’ in adult patients, Parkinsonism
Target: Adrenergic receptor
PDIDE001
Ebastine
Active compound: Carebastine
Indications: Allergic rhinitis
Target: H1-receptor
PDIDE012
Estradiol benzoate
Active compound: Estradiol
Indications: Terminate pregnancy; Menstrual disorder; Prostate cancer
Target: Estrogen Receptor (ER) including ERα and ERβ subtypes
PDIDE013
Estradiol cypionate
Active compound: Estradiol
Indications: Moderate to severe vasomotor symptoms associated with menopause; Hypoestrogenism due to hypogonadism
Target: Estrogen Receptor (ER) including ERα and ERβ subtypes; NR3A (ESR)(KEGG)
PDIDE021
Ethyl 2-acetamido-3-(3,4-diacetyloxyphenyl)propanoate
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDF001
Famciclovir
Active compound: Penciclovir
Indications: Herpesvirus infections; varicella zoster virus (VZV)
Target: DNA polymerase catalytic subunit
PDIDF002
Faropenem Medoxomil
Active compound: Faropenem
Indications: Bacterial infection (staphilococcus)
Target: Peptidoglycan synthase FtsI
PDIDF007
Fingolimod
Active compound: Fingolimod-phosphate
Indications: Multiple sclerosis
Target: Sphingosine 1-phosphate (S1P) receptor
PDIDF008
Flucytosine
Active compound: 5-Fluorouridine 5'-triphosphate
Indications: Candida or Cryptococcus neoformans fungal infections
Target: DNA
PDIDF018
Fosciclopirox (CPX-POM)
Active compound: Ciclopirox
Indications: Advanced solid tumors
Target: na
PDIDF020
Fosinopril
Active compound: Fosinoprilat
Indications: Hypertension and congestive heart failure
Target: Angiotensin-converting-enzyme
PDIDF024
Fostamatinib
Active compound: R406
Indications: Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP)
Target: Spleen tyrosine kinase; adenosine a3 receptor; adenosine and monoamine uptake transporters; udp glucuronosyltransferase ugt1a1; phosphodiesterase pde5; fatty acid amide hydrolase; 5-lipoxygenase, cathepsin l; and cathepsin s
PDIDF025
Fostemsavir
Active compound: Temsavir
Indications: HIV-1
Target: gp120 molecule on Virus surface (Ref 1)
PDIDF027
FTI 277
Active compound: FTI 276
Indications: Multiple myeloma
Target: Farnesyl transferase
PDIDF028
Fursultiamine
Active compound: Thiamine
Indications: Vitamine B1 deficiency
Target: na
PDIDG001
Gabapentin Enacarbil
Active compound: Gabapentin
Indications: Adult Restless Legs Syndrome; postherpetic neuralgia
Target: Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-dependent calcium channel subunit alpha-2/delta-2
PDIDG003
Ganciclovir
Active compound: Ganciclovir Triphosphate
Indications: Herpes Simplex Virus infection
Target: DNA polymerase catalytic subunit; viral DNA polymerases; Thymidine kinase
PDIDG006
Glycerol phenylbutyrate
Active compound: Phenylacetate
Indications: Urea cycle disorders (UCDs)
Target: Glutamine
PDIDG008
Glycovir
Active compound: Miglustat
Indications: HIV Infections (WL1, WL2)
Target: Alpha-glucosidase 1 (WL2)
PDIDI004
Imidapril
Active compound: Imidaprilat
Indications: Hypertension
Target: Angiotensin-converting-enzyme
PDIDI007
Irinotecan (CPT-11)
Active compound: 7-ethyl-10-hydroxycamptothecin
Indications: Colon cancer
Target: Topoisomerase I
PDIDJ001
JM6
Active compound: Ro 61-8048
Indications: Alzheimer
Target: Kynurenine 3-monooxygenase
PDIDL002
Lagociclovir valactate
Active compound: 3'-fluoro-2', 3'-dideoxyguanosine
Indications: HBV, HIV (WL1)
Target: Nucleoside reverse transcriptase (WL1)
PDIDL006
Latanoprostene bunod
Active compound: Latanoprost acid
Indications: Glaucoma
Target: Prostaglandin F2-alpha receptor
PDIDL009
Lenampicillin
Active compound: Ampicillin
Indications: Bacterial infections
Target: Enzyme transpeptidase
PDIDL019
LY2140023
Active compound: LY404039
Indications: Psychosis and schizophrenia
Target: Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 3
PDIDM002
MB07811
Active compound: MB07344
Indications: Hyperlipidemia
Target: Thyroid hormone receptor beta
PDIDM007
Mepitiostane
Active compound: Epitiostanol
Indications: Breast cancer
Target: Estrogen receptor alpha; Estrogen receptor beta
PDIDM008
Mericitabine
Active compound: PSI-6130-TP (Metabolite 1)
Indications: Hepatitis C
Target: NS5B HCV RNA-dependent RNA polymerase
PDIDM008
Mericitabine
Active compound: Uridine-triphosphate (Metabolite 2)
Indications: Hepatitis C
Target: NS5B HCV RNA-dependent RNA polymerase
PDIDM011
Mestranol
Active compound: Ethinyl estradiol
Indications: Oral contraceptives
Target: Estrogen receptor alpha (WL1, WL2); estrogen receptor beta (WL2)
PDIDM020
Midodrine
Active compound: Desglymidodrine (DMAE)
Indications: Dysautonomia and orthostatic hypotension
Target: Alpha-adrenergic receptors
PDIDM029
Moxisylyte
Active compound: Deacetylthymoxamine
Indications: Erectile dysfunction
Target: α1-adrenergic antagonist
PDIDN004
NB-355
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDO002
Olmesartan hexetil
Active compound: Olmesartan
Indications: Hypertension
Target: Type 1 angioten-sin II receptors (AT1-R)
PDIDO003
Olmesartan Medoxomil
Active compound: Olmesartan
Indications: Cardiovascular disease, Heart failure, and Renal disease; Hypertension and Type 2 Diabetes-associated nephropathy
Target: Angiotensin II type 1 receptor
PDIDO007
Oseltamivir
Active compound: Oseltamivir carboxylate
Indications: Influenza A and Influenza B
Target: Neuraminidase
PDIDP003
Pafuramidine
Active compound: Furamidine
Indications: Pneumocystis pneumonia
Target: na
PDIDP018
Pivampicillin
Active compound: Ampicillin
Indications: Respiratory tract infections; Ear, nose and throat infections; Gynecological infections; Urinary tract infections
Target: Enzyme transpeptidase
PDIDP023
Pradefovir
Active compound: Adefovir
Indications: Hepatitis B
Target: Adevofir diphosphate inhibition of RNA-dependent DNA polymerase (By competing with natural dATPs)
PDIDP024
Prasugrel
Active compound: R-138727
Indications: Acute Coronary Syndrome (ACS); unstable angina (UA); non-ST elevation myocardial infarction (NSTEMI); ST-elevation myocardial infarction (STEMI)
Target: ADP receptor
PDIDP039
Proguanil
Active compound: Cycloguanil
Indications: Malaria (Plasmodium falciparum and Plasmodium vivax)
Target: Dihydrofolate reductase
PDIDQ002
Quinapril
Active compound: Quinaprilat
Indications: Hypertension and congestive heart failure
Target: Angiotensin-converting-enzyme
PDIDR002
R-348
Active compound: R333
Indications: Autoimmune diseases
Target: Janus Kinase 3
PDIDR005
Racecadotril
Active compound: Thiorphan
Indications: Acute diarrhea
Target: Neutral endopeptidase/ Enkephalinase
PDIDR006
Ramipril
Active compound: Ramiprilat
Indications: Hypertension and congestive heart failure
Target: Angiotensin-converting-enzyme
PDIDA032
AKOS024372695
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS005
SCHEMBL1068518
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS006
SCHEMBL1069483
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS007
SCHEMBL1070495
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS008
SCHEMBL14377320
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS010
SCHEMBL15272458
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDA034
Alalevonadifloxacin
Active compound: Levonadifloxacin
Indications: Acute bacterial skin and skin structure infections (ABSSSI)
Target: DNA gyrase
PDIDS023
SCHEMBL4809664
Active compound: Eglumetad
Indications: Psychosis, anxiety, anddrug withdrawal
Target: Group II metabotropic glutamate (mGlu) receptors
PDIDS025
SCHEMBL6372980
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS028
SCHEMBL7441616
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDS029
SCHEMBL8504774
Active compound: L014097
Indications: Depression
Target: Non-peptide NK1 neurokinin receptor
PDIDA035
Alamifovir
Active compound: SCHEMBL6664903
Indications: Hepatitis B virus
Target: Inhibiting viral DNA priming and viral DNA packaging
PDIDS040
SNX-5422
Active compound: SNX-2112
Indications: Breast, lung, and ovarian cancer
Target: Heat shock protein HSP 90
PDIDS042
Spirapril
Active compound: Spiraprilat
Indications: Hypertension
Target: Angiotensin-converting-enzyme
PDIDT009
Tebipenem-pivoxil
Active compound: Tebipenem
Indications: Otolaryngologic and respiratory infections in pediatric patients
Target: Penicillin-binding proteins (PBPs)
PDIDT012
Tegafur
Active compound: 5-Fluorouracil
Indications: Candida or Cryptococcus neoformans fungal infections
Target: Thymidylate Synthase (TS)
PDIDT014
Telotristat ethyl
Active compound: Telotristat
Indications: Carcinoid syndrome
Target: Tryptophan hydroxylase (tph)
PDIDT018
Tenofovir alafenamide
Active compound: Tenofovir
Indications: Hepatitis B; HIV-1 infection
Target: Reverse transcriptase/RNaseH; Reverse transcriptase; DNA polymerase (Drug Bank)
PDIDT027
Testosterone undecanoate
Active compound: Testosterone
Indications: Absence or deficiency in endogenous testosterone production
Target: Androgen receptor
PDIDT030
Ticlopidine
Active compound: Thiol Metabolite of Ticlopidine
Indications: Strokes and coronary stent occlusions
Target: P2Y purinoceptor 12; Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1)
PDIDT032
Tinidazole
Active compound: Metronidazole
Indications: Bacterial vaginosis (BV); giardiasis and amoebiasis
Target: DNA
PDIDT042
Trestolone acetate
Active compound: 19-nortestosterone
Indications: To promoting muscle growth in cattle
Target: Androgen receptor; progesterone receptor (ref 1)
PDIDA042
ALS-8176
Active compound: ALS-8112
Indications: RSV infection
Target: RSV polymerase
PDIDV001
Valaciclovir
Active compound: Acyclovir
Indications: Herpes Zoster; Suppression of genital herpes lesions in immunocompetent or HIV-infected patients; Cold Sores (Herpes Labialis); Chickenpox
Target: HSV-specified DNA polymerases
PDIDV003
Valganciclovir
Active compound: Ganciclovir
Indications: Cytomegalovirus infections
Target: DNA polymerase, Thymidine kinase of HHV1
PDIDV005
Valopicitabine
Active compound: 2'-c-Methylcytidine
Indications: Hepatitis C
Target: HCV RNA polymerase
PDIDX001
Ximelagatran
Active compound: Melagatran
Indications: Anticoagulant, venous thromboembolism
Target: Thrombin
PDIDY001
Y-27152
Active compound: Y-26763
Indications: Hypertension
Target: Potassium channel
PDIDP049
Paclitaxel-2-ethylcarbonate
Active compound: Paclitaxel
Indications: Breast, ovary and lung cancer
Target: Tubulin
PDIDOTH020
5-Ethynyl-2(1H)-pyrimidinone
Active compound: 5-Ethynyluracil
Indications: Colorectal, breast, gastric, head and neck, ovarian and basal cell cancer of the skin
Target: Dihydropyrimidine dehydrogenase (DPD)
PDIDA047
Ampiroxicam
Active compound: Piroxicam
Indications: Rheumatoid arthritis and osteoarthritis
Target: Cyclooxygenase (COX)
PDIDA049
ANA971
Active compound: Isatoribine
Indications: Hepatitis C virus
Target: Toll-like receptor 7
PDIDOTH007
1-Androsterone
Active compound: Dehydroepiandrosterone
Indications: Potential chemopreventive activity,immunologic adjuvants
Target: na
PDIDA050
Androstanolone benzoate
Active compound: Dihydrotestosterone
Indications: Na
Target: Androgen receptor
PDIDA066
Azilsartan Medoxomil
Active compound: Azilsartan
Indications: Essential hypertension
Target: Type-1 angiotensin II receptor
PDIDB001
Bacampicillin
Active compound: Ampicillin
Indications: Bacterial infections
Target: Enzyme transpeptidase
PDIDOTH009
3,4-Bis(ethoxycarbonyloxy)benzeneethanamine
Active compound: Dopamine
Indications: Parkinson’s disease (PD)
Target: Dopamine receptor
PDIDB007
Beclometasone dipropionate
Active compound: Beclomethasone 17-monopropionate
Indications: Asthma and rhinitis
Target: Nuclear receptors
PDIDB008
Benazepril
Active compound: Benazeprilat
Indications: Hypertension, congestive heart failure, and heart attacks,
Target: Acetylcholinase esterase
PDIDB009
Benzhydrocodone
Active compound: Hydrocodone
Indications: Acute pain
Target: mu-opioid receptor