Showing results for 'Others'
Total number of hits: 56
Click on results for more details:
PDIDB015
Bimatoprost
Active compound: 17-Phenyl-Trinor-PGF2alpha
Indications: Glaucoma, ocular hypertension
Target: Prostaglandin receptors
PDIDB028
Bopindolol
Active compound: 4-(2-Hydroxy-3-tert-butylaminopropoxy)-2-methylindole
Indications: Hypertension
Target: β1- and β2- adrenoceptors
PDIDC011
CDB-4754
Active compound: 11β-MNT
Indications: Na
Target: na
PDIDOTH013
4-Chlorokynurenine
Active compound: 7-chlorokynurenic acid
Indications: Prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma
Target: N-methyl-D-aspartate (NMDA) receptor
PDIDOTH017
5-FP
Active compound: 5-FU
Indications: liver, lung, adrenal, testis, and prostate cancers
Target: Thymidylate synthase
PDIDOTH019
9-ACG
Active compound: 9-AC
Indications: Cancer
Target: Beta-glucuronidase-positive cells
PDIDOTH002
1,4-Butanediol
Active compound: γ-hydroxybutyrate
Indications: Myeloproliferative disease; Narcolepsy
Target: GABA-B receptor; DNA
PDIDC091
Cinazepam
Active compound: 3-Hydroxyphenazepam
Indications: Anxiety, insomnia, muscle spasm, alcohol withdrawal and seizures
Target: Benzodiazepine receptors
PDIDC111
Cyclophosphamide
Active compound: 4-Hydroxy-cyclophosphamide
Indications: Cancers, autoimmune disorders, and al amyloidosis
Target: DNA (alkylating agent)
PDIDD003
Dacarbazine
Active compound: 5-Aminoimidazole-4-Carboxamide
Indications: malignant melanoma, Hodgkin's lymphoma, sarcoma, and islet cell carcinoma of the pancreas.
Target: na
PDIDD008
Deflazacort
Active compound: 21-desacetyldeflazacort
Indications: Duchenne muscular dystrophy
Target: Glucocorticoid receptor
PDIDD010
Delapril
Active compound: 5-hydroxydelapril diacid
Indications: Hypertension and heart failure
Target: Converting enzyme inhibitor (CEI); ACE inhibitor
PDIDD012
Desogestrel
Active compound: 3-keto-desogestrel
Indications: Contraception
Target: Progesterone receptor, Estrogen receptor
PDIDD025
Dirithromycin
Active compound: 9S-erythromycyclamine
Indications: Bronchitis; Pneumonia; Tonsillitis; Skin infections
Target: 23S-component of the 50S-subunit of prokaryotic ribosomes
PDIDD029
Doxifluridine
Active compound: 5-Fluorouracil
Indications: Stomach cancer; Breast cancer
Target: Thymidylate synthase
PDIDE017
Estradiol Valerate
Active compound: 17β-estradiol
Indications: Infertility, hormone replacement therapy
Target: Estrogen receptor
PDIDF004
F-dAdo
Active compound: 2-Fluoroadenine
Indications: Tumors
Target: Purine nucleoside phosphorylase DeoD-type
PDIDF006
Fesoterodine
Active compound: 5-hydroxymethyltolterodine
Indications: Urinary incontinence
Target: M2 and M3 muscarinic receptors
PDIDF008
Flucytosine
Active compound: 5-Fluorouridine 5'-triphosphate
Indications: Candida or Cryptococcus neoformans fungal infections
Target: DNA
PDIDOTH003
11β-Methyl-19-nortestosterone dodecylcarbonate
Active compound: 11β-MNT
Indications: Birth control pill for men
Target: Androgen receptor; Progesterone receptor (Ref 1)
PDIDA013
AC1LAHXM
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDA014
AC1LAHXP
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDA015
AC1LAHXS
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDI003
Ifosfamide
Active compound: 4-hydroxyifosfamide
Indications: Cancer
Target: DNA
PDIDI007
Irinotecan (CPT-11)
Active compound: 7-ethyl-10-hydroxycamptothecin
Indications: Colon cancer
Target: Topoisomerase I
PDIDA016
AC1LAHZV
Active compound: 3'-Fluoro-3'-deoxythymidine
Indications: HIV infection
Target: Reverse Transcriptase
PDIDL002
Lagociclovir valactate
Active compound: 3'-fluoro-2', 3'-dideoxyguanosine
Indications: HBV, HIV (WL1)
Target: Nucleoside reverse transcriptase (WL1)
PDIDA018
AC1MHEO9
Active compound: 2-Amino-6-methoxypurine analogue
Indications: Cytomegalo Virus Infection
Target: DNA
PDIDM006
MeP-dR
Active compound: 6-Methylpurine
Indications: Tumors
Target: Purine nucleoside phosphorylase DeoD-type
PDIDM018
Metrifonate
Active compound: 2,2-dichlorovinyl Dimethyl Phosphate (DDVP)
Indications: Schistosomiasis; Alzheimer’s disease
Target: Acetylcholinesterase (AChE)
PDIDOTH004
125IQ2-P
Active compound: 125IQ2-OH
Indications: Cancer
Target: na
PDIDN001
Nabumetone
Active compound: 6-methoxy-2-naphthylacetic Acid
Indications: Rheumatoid arthritis; Osteoarthritis
Target: Prostaglandin G/H synthase 2
PDIDN005
Nelarabine
Active compound: 9-ß-D-arabinofuranosylguanine
Indications: T-cell acute lymphoblastic leukemia (ALL) and lymphoma (LBL)
Target: DNA
PDIDO004
Olsalazine
Active compound: 5-aminosalicylic Acid
Indications: Inflammatory Bowel Disease and Ulcerative Colitis
Target: Prostaglandin G/H synthase
PDIDQ001
Quercetin
Active compound: 3-Hydroxyphenylacetic acid
Indications: Lung, ovary and breast cancer
Target: Tyrosine kinases
PDIDR001
R13
Active compound: 7,8-dihydroxyflavone
Indications: Cervical cancer; Alzheimer's disease
Target: Tropomyosin receptor kinase B (TrkB) (WL1)
PDIDR003
R7
Active compound: 7,8-dihydroxyflavone
Indications: Cervical cancer; Alzheimer's disease
Target: Tropomyosin receptor kinase B (TrkB) (WL1)
PDIDOTH005
1-Androstenediol
Active compound: 1-testosterone
Indications: Stimulates the growth of the prostate as well as the seminal vesicles; Enhance athletic performance
Target: na
PDIDS026
SCHEMBL6711678
Active compound: 6-Mercaptopurine
Indications: Colon and breast carcinoma
Target: DNA
PDIDS047
Sulfasalazine
Active compound: 5-aminosalicylic Acid
Indications: Rheumatoid arthritis
Target: Prostaglandin G/H synthase
PDIDT012
Tegafur
Active compound: 5-Fluorouracil
Indications: Candida or Cryptococcus neoformans fungal infections
Target: Thymidylate Synthase (TS)
PDIDT017
Temozolomide
Active compound: 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC)
Indications: Brain cancers, astrocytoma, glioblastoma multiforme
Target: DNA (alkylating agent)
PDIDT023
Testosterone
Active compound: 5-dihydrotestosterone (DHT)
Indications: Primary hypogonadism and hypogonadotropic hypogonadism
Target: Androgen receptor
PDIDT035
Tolterodine
Active compound: 5-Hydroxymethyltolterodine (5-HMT)
Indications: Urinary incontinence
Target: M2 and M3 muscarinic receptors
PDIDOTH006
1-Androstenedione
Active compound: 1-testosterone
Indications: Stimulates the growth of the prostate as well as the seminal vesicles; Enhance athletic performance
Target: na
PDIDA041
Allylestrenol
Active compound: 17α-allyl-19-nortestosterone
Indications: Treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women
Target: Progesterone, androgen and glucocorticoid receptors
PDIDT042
Trestolone acetate
Active compound: 19-nortestosterone
Indications: To promoting muscle growth in cattle
Target: Androgen receptor; progesterone receptor (ref 1)
PDIDT043
Tretazicar
Active compound: 5-(aziridin-1-yl)-4-acetoxy-2-nitrobenzamide
Indications: Tumours
Target: DNA
PDIDV005
Valopicitabine
Active compound: 2'-c-Methylcytidine
Indications: Hepatitis C
Target: HCV RNA polymerase
PDIDOTH020
γ-Hydroxybutyraldehyde
Active compound: γ-hydroxybutyric acid
Indications: Na
Target: na
PDIDOTH021
Γ-Valerolactone
Active compound: γ-hydroxyvaleric acid
Indications: Na
Target: GHB receptor
PDIDOTH020
5-Ethynyl-2(1H)-pyrimidinone
Active compound: 5-Ethynyluracil
Indications: Colorectal, breast, gastric, head and neck, ovarian and basal cell cancer of the skin
Target: Dihydropyrimidine dehydrogenase (DPD)
PDIDOTH008
2,4-Dopa
Active compound: 6-Hydroxydopa
Indications: Malignant melanoma
Target: DNA, RNA, and protein synthesis
PDIDA065
Azathioprine
Active compound: 6-Mercaptopurine
Indications: Cancer, autoimmune disorders and in organ transplant
Target: Hypoxanthine-guanine phosphoribosyltransferase
PDIDB003
Balsalazide
Active compound: 5-aminosalicylic Acid
Indications: Ulcerative colitis
Target: Prostaglandin G/H synthase; Peroxisome proliferator-activated receptor gamma; Arachidonate 5-lipoxygenase
PDIDB010
Benznidazole
Active compound: 2-nitroimidazole
Indications: Chagas disease
Target: Proteins, DNA/RNA