Showing results for 'Absorption'
Total number of hits: 70
Click on results for more details:
PDIDC002
Candoxatril
Active compound: Candoxatrilat
Indications: heart failure
Target: Neutral endopeptidase and ACE
PDIDC014
Cefcapene pivoxil
Active compound: Cefcapene
Indications: Palmoplantar pustulosis (PPP), Bacterial Infections
Target: Penicillin binding protein
PDIDC015
Cefditoren pivoxil
Active compound: Cefditoren
Indications: Throat and lung infections, including bronchitis and tonsillitis
Target: Penicillin binding protein
PDIDC017
Cefpodoxime Proxetil
Active compound: Cefpodoxim
Indications: Gram-positive and Gram-negative bacterial infection
Target: Penicillinases and cephalosporinases
PDIDC019
Cefteram pivoxil
Active compound: Cefteram
Indications: Laryngopharyngitis,tonsillitis, acute bronchitis, pneumonia, chronic bron-chitis, diffuse panbronchiolitis, infected bronchiec-tasis and other infective chronic respiratory diseases
Target: Penicillin binding protein
PDIDC022
Cefuroxime axetil
Active compound: Cefuroxime
Indications: Bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Target: Penicillin-binding protein 1A
PDIDOTH002
1,4-Butanediol
Active compound: γ-hydroxybutyrate
Indications: Myeloproliferative disease; Narcolepsy
Target: GABA-B receptor; DNA
PDIDA001
Abiraterone acetate
Active compound: Abiraterone
Indications: Prostate cancer
Target: 17 α-hydroxylase/C17,20-lyase (CYP17)
PDIDC089
Cidofovir
Active compound: Cidofovir diphosphate
Indications: Cytomegalovirus (CMV)
Target: Viral DNA
PDIDC098
Clofibride
Active compound: clofibric acid
Indications: Obesity complicated with cardiac disorders
Target: na
PDIDC101
Clostebol acetate
Active compound: Clostebol
Indications: Used as dermatological ointment, Banned performance enhancing drug
Target: na
PDIDC102
Clostebol caproate
Active compound: Clostebol
Indications: Banned performance enhancing drug
Target: na
PDIDC103
Clostebol propionate
Active compound: Clostebol
Indications: Banned performance enhancing drug
Target: na
PDIDC105
CMX-157
Active compound: Tenofovir
Indications: Hiv infections and chronic hepatitis b
Target: Cellular Reverse Transcriptase inhibitor
PDIDC111
Cyclophosphamide
Active compound: 4-Hydroxy-cyclophosphamide
Indications: Cancers, autoimmune disorders, and al amyloidosis
Target: DNA (alkylating agent)
PDIDD002
Dabigatran etexilate
Active compound: Dabigatran
Indications: Venous thromboembosis
Target: Prothrombin enzyme
PDIDD008
Deflazacort
Active compound: 21-desacetyldeflazacort
Indications: Duchenne muscular dystrophy
Target: Glucocorticoid receptor
PDIDE003
Enalapril
Active compound: Enalaprilat
Indications: Hypertension, symptomatic heart failure, and asymptomatic left ventricular dysfunction
Target: Angiotensin-converting-enzyme inhibitor
PDIDE010
Esomeprazole
Active compound: Hydroxyomeprazole
Indications: Acid-reflux disorders; Gastroesophageal reflux disease (GERD); Bacterial Infection Due to Helicobacter Pylori (H. Pylori); Zollinger-Ellison Syndrome
Target: (H+,K+)-ATPase
PDIDE012
Estradiol benzoate
Active compound: Estradiol
Indications: Terminate pregnancy; Menstrual disorder; Prostate cancer
Target: Estrogen Receptor (ER) including ERα and ERβ subtypes
PDIDE013
Estradiol cypionate
Active compound: Estradiol
Indications: Moderate to severe vasomotor symptoms associated with menopause; Hypoestrogenism due to hypogonadism
Target: Estrogen Receptor (ER) including ERα and ERβ subtypes; NR3A (ESR)(KEGG)
PDIDG004
Gemcitabine
Active compound: Gemcitabin triphosphat (Metabolite 2)
Indications: Ovarian cancer; Metastatic (Stage IV) non-small cell lung cancer; metastatic (Stage IV) adenocarcinoma of the pancreas
Target: DNA
PDIDG004
Gemcitabine
Active compound: Gemcitabine diphosphate (Metabolite 1)
Indications: Ovarian cancer; Breast Cancer
Target: Ribonucleotide reductase
PDIDH003
Hetacillin
Active compound: Ampicillin
Indications: Bacterial Infections
Target: Penicillin-binding proteins (PBPs) which includes transpeptidases, carboxypeptidases, and endopeptidases
PDIDH004
Histidine-Leucine-Lopinavir
Active compound: Lopinavir
Indications: HIV,Retroviral infections
Target: Human immunodeficiency virus type 1 protease
PDIDL007
Leflunomide
Active compound: Teriflunomide
Indications: Rheumatoid arthritis (RA) and psoriatic arthritis
Target: Dihydroorotate dehydrogenase (quinone), mitochondrial
PDIDL015
Loperamide Oxide
Active compound: Loperamide
Indications: Diarrhea
Target: μ-opioid receptors
PDIDL018
Loxoprofen
Active compound: Loxoprofen trans-OH metabolite
Indications: Musculoskeletal and joint disorders
Target: Prostaglandin G/H synthase 2; Prostaglandin G/H synthase 1
PDIDA021
Aceburic acid
Active compound: Gamma-hydroxybutyrate
Indications: Anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
Target: Cell specific
PDIDM023
Miproxifene phosphate
Active compound: Miproxifene
Indications: Breast cancer (Ref 1)
Target: Estrogen receptor (ER) (R1)
PDIDM030
Mycophenolate Mofetil
Active compound: Mycophenolic Acid (MPA)
Indications: Used as immunosuppressant in solid-organ transplantation; Autoimmune hepatitis
Target: Inosine monophosphate dehydrogenase (impdh)
PDIDN006
Nepafenac
Active compound: Amfenac
Indications: Pain and inflammation
Target: Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2)
PDIDN010
Norethisterone acetate
Active compound: Norethisterone
Indications: Amenorrhea, functional uterine bleeding, endometriosis, and for contraception (Ref 1)
Target: Progesterone receptor (Ref 2)
PDIDA023
Aceglutamide
Active compound: L-glutamine
Indications: Sickle cell disease
Target: Cell specific
PDIDO001
O-Acetylpsilocin
Active compound: Psilocin
Indications: na
Target: na
PDIDO004
Olsalazine
Active compound: 5-aminosalicylic Acid
Indications: Inflammatory Bowel Disease and Ulcerative Colitis
Target: Prostaglandin G/H synthase
PDIDP019
Pivmecillinam
Active compound: Mecillinam
Indications: Urinary tract infections, salmonellosis and typhoid fever (WL1)
Target: Penicillin-binding protein 1A
PDIDP027
Prednisone
Active compound: Prednisolone
Indications: Drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis
Target: Glucocorticoid receptor
PDIDP036
Primidone
Active compound: phenylethylmalonamide (PEMA)
Indications: Partial and generalized seizures
Target: Gamma-aminobutyric acid receptors
PDIDP036
Primidone
Active compound: Phenobarbital
Indications: Partial and generalized seizures
Target: Gamma-aminobutyric acid receptors
PDIDP037
Procarbazine
Active compound: Azoprocarbazine
Indications: Brain tumors and Hodgkin's lymphoma
Target: DNA (alkylating agent)
PDIDQ003
Quingestanol
Active compound: Norethisterone
Indications: Endometriosis-related pain; Postmenopausal osteoporosis and moderate-to-severe vasomotor symptoms arising from menopause
Target: Progesterone receptor
PDIDQ004
Quingestanol acetate
Active compound: Norethisterone
Indications: Oral contraceptives
Target: Progesterone receptor
PDIDR002
R-348
Active compound: R333
Indications: Autoimmune diseases
Target: Janus Kinase 3
PDIDR010
Rescula
Active compound: Unoprostone
Indications: Occular Hypertension
Target: na
PDIDS001
Sacubitril
Active compound: Sacubitrilat
Indications: Reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction
Target: Neprilysin (WL1)
PDIDS003
SB 204990
Active compound: SB 201076
Indications: Hypolipidaemia
Target: ATP citrate (pro-S)-lyase
PDIDS031
Secnidazole
Active compound: Secnidazole active nitro radical
Indications: Bacterial vaginosis in adult women
Target: Bacterial DNA synthesis
PDIDS045
Stenbolone acetate
Active compound: Dihydrotestosterone
Indications: Na
Target: Androgen receptor
PDIDS047
Sulfasalazine
Active compound: 5-aminosalicylic Acid
Indications: Rheumatoid arthritis
Target: Prostaglandin G/H synthase
PDIDS047
Sulfasalazine
Active compound: Sulfapyridine
Indications: Rheumatoid arthritis
Target: Prostaglandin G/H synthase
PDIDS048
Sulindac
Active compound: Sulindac Sulfide
Indications: Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder and acute gouty arthritis
Target: Prostaglandin G/H synthase 2
PDIDS049
Sultamicillin
Active compound: Ampicillin
Indications: Pneumonia and Chronic Obstructive Pulmonary Disease (COPD)
Target: Enzyme transpeptidase
PDIDT006
Tamoxifen
Active compound: Afimoxifene
Indications: Breast cancer
Target: Estrogen receptor
PDIDT006
Tamoxifen
Active compound: Endoxifen
Indications: Breast cancer
Target: Estrogen receptor
PDIDA038
Alestramustine
Active compound: Estramustine
Indications: Metastatic and/or progressive carcinoma of the prostate
Target: Microtubule-associated proteins and β-tubulin
PDIDT009
Tebipenem-pivoxil
Active compound: Tebipenem
Indications: Otolaryngologic and respiratory infections in pediatric patients
Target: Penicillin-binding proteins (PBPs)
PDIDT016
Temocapril
Active compound: Temocaprilat
Indications: Hypertension and congestive heart failure, diabetic nephropathy (WL2)
Target: Angiotensin converting enzyme (ACE) (R1)
PDIDT019
Tenofovir Disoproxil
Active compound: Tenofovir
Indications: HIV/AIDS and hepatitis B
Target: Reverse Transcriptase
PDIDA041
Allylestrenol
Active compound: 17α-allyl-19-nortestosterone
Indications: Treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women
Target: Progesterone, androgen and glucocorticoid receptors
PDIDT038
Travoprost
Active compound: Travoprost free acid
Indications: Glaucoma or ocular hypertension
Target: FP prostanoid receptor
PDIDT044
Triclofos
Active compound: Trichloroethanol
Indications: Insomnia
Target: na
PDIDV008
Valtorcitabine
Active compound: Torcitabine triphosphate
Indications: Hepatitis B
Target: HBV polymerase
PDIDV010
VX-765
Active compound: VRT-043198
Indications: Inflamation, Psoriasis and psoriatic disorders
Target: ICE/caspase-1 sub-family caspases
PDIDA056
Arbaclofen placarbil
Active compound: R-baclofen
Indications: Treatment for patients with GERD and spasticity due to multiple sclerosis
Target: Gamma-aminobutyric acid type B receptor subunit 1; Gamma-aminobutyric acid type B receptor subunit 2
PDIDA064
Avizafone
Active compound: Diazepam
Indications: Anxiolytic agent and muscle relaxant,premediation for anesthesia, a sedative for minor surgery or invasive procedures, and for treatment of status epileptus or severe recurrent seizures
Target: Acetylcholinesterase
PDIDA065
Azathioprine
Active compound: 6-Mercaptopurine
Indications: Cancer, autoimmune disorders and in organ transplant
Target: Hypoxanthine-guanine phosphoribosyltransferase
PDIDB003
Balsalazide
Active compound: 5-aminosalicylic Acid
Indications: Ulcerative colitis
Target: Prostaglandin G/H synthase; Peroxisome proliferator-activated receptor gamma; Arachidonate 5-lipoxygenase
PDIDB013
Besifovir
Active compound: LB80317
Indications: Hepatitis B(HBV) infection
Target: Tissue
PDIDB014
Bezitramide
Active compound: Despropionyl-bezitramide
Indications: Severe chronic pain
Target: na